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- 6:32 am
- Sunday
- September 26, 2021
| 1:00 PM | At Buffalo | -4 | Denver | 37 | | |
| 1:00 PM | At Atlanta | -3.5 | Tampa Bay | 52 | | |
| 1:00 PM | At Philadelphia | -1 | Seattle | 47 | | |
| 1:00 PM | At Chicago | -6 | New York (N) | 40.5 | | |
| 1:00 PM | At New Orleans | -10 | Carolina | 46.5 | | |
| 1:00 PM | At Cleveland | -10.5 | Miami | 46 | | |
| 1:00 PM | Pittsburgh | -6.5 | At Cincinnati | 38 | | |
| 1:00 PM | Oakland | -3 | At New York (A) | 46.5 | | |
| 1:00 PM | Detroit | -3.5 | At Washington | 40 | | |
| 4:05 PM | At Tennessee | -3.5 | Jacksonville | 41.5 | | |
| 4:25 PM | At New England | -6 | Dallas | 45 | | |
| 8:20 PM | At San Francisco | -3 | Green Bay | 47.5 | | |
| 8:15 PM | Baltimore | -3 | At Los Angeles (N) | 46.5 | | |
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